S-adenosylmethionine (SAMe) is a naturally occurring substance that plays an important role in metabolism as a methyl group donor. This amino acid derivative is formed from ATP (adenosine triphosphate) and the essential amino acid methionine, with the removal of pyrophosphate and phosphate. SAMe is found in very limited quantities in food, unlike its precursor, methionine, from which it is formed in the body. Vitamins B12 and folic acid are necessary for the endogenous synthesis of S-adenosylmethionine. Pure Encapsulations SAMe (S-adenosyl-methionine) has been encapsulated using innovative galenic agents called "DRcaps," which protect the sensitive ingredient from stomach acid.
 S-adenosylmethionine (SAMe) has antidepressant, stimulant, and hepatoprotective properties. It actively penetrates the blood-brain barrier and stimulates the synthesis of dapamine.